Hippo tips the TGF-β scale in favor of pluripotency.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24388171.
- Also identified by DOI 10.1016/j.stem.2013.12.009 and PMC identifier 3941189.
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Abstract
How TGF-β signaling switches from enforcing pluripotency to promoting mesendodermal differentiation remains an open question. Recently in Cell Reports, Beyer et al. demonstrated that Hippo signaling components recruit the NuRD complex to repress expression of key genes targeted by TGF-β and thus determine whether TGF-β signaling will favor pluripotency or differentiation.
Medical subject headings
- Cell Differentiation
- Embryonic Stem Cells
- Pluripotent Stem Cells
- Protein Serine-Threonine Kinases
- Smad2 Protein
- Smad3 Protein
- Transforming Growth Factor beta