Nanofilaments on glioblastoma exosomes revealed by peak force microscopy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24402921.
- Also identified by DOI 10.1098/rsif.2013.1150 and PMC identifier 3899882.
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Abstract
Exosomes are sub-100 nm extracellular vesicles secreted by normal and cancer cells. We present a high-resolution structure of previously unidentified nanofilaments on glioblastoma-derived exosomes, using nanoscale peak force imaging. These stiff, adhesive, trypsin- and RNAse-resistant surface nanofilaments add a new dimension to the current structural knowledge of exosome-mediated intercellular communication.
Medical subject headings
- Cell Communication
- Cytoskeleton
- Exosomes
- Glioblastoma
- Models, Biological