Repair of large full-thickness cartilage defect by activating endogenous peripheral blood stem cells and autologous periosteum flap transplantation combined with patellofemoral realignment.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 24405791.
- Also identified by DOI 10.1016/j.knee.2013.10.010.
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Abstract
Minimal-invasive procedure and one-step surgery offer autologous mesenchymal stem cells derived from peripheral blood (PB-MSCs) a promising prospective in the field of cartilage regeneration. We report a case of a 19-year-old male athlete of kickboxing with ICRS grade IV chondral lesions at the 60° region of lateral femoral trochlea, which was repaired by activating endogenous PB-MSCs plus autologous periosteum flap transplantation combined with correcting the patellofemoral malalignment. After a 7.5 year follow-up, the result showed that the patient returned to competitive kickboxing. Second-look under arthroscopy showed a smooth surface at 8 months postoperation. The IKDC 2000 subjective score, Lysholm score and Tegner score were 95, 98 and 9 respectively at the final follow up. CT and MRI evaluations showed a significant improvement compared with those of pre-operation.
Medical subject headings
- Bone Malalignment
- Cartilage, Articular
- Patellofemoral Joint
- Periosteum
- Peripheral Blood Stem Cell Transplantation
- Tibia
Anatomy
- femur
- knee
- tibia