Poly(3-hydroxybutyrate-co-R-3-hydroxyhexanoate) nanoparticles with polyethylenimine coat as simple, safe, and versatile vehicles for cell targeting: population characteristics, cell uptake, and intracellular trafficking.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24408356.
- Also identified by DOI 10.1002/adhm.201300533.
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Abstract
A simple and highly safe poly(3-hydroxybutyrate-co-R-3-hydroxyhexanoate) nanoparticulate delivery system that targets different cell types is developed. A sub-cytotoxic level of polyethylenimine coat mediates universal cell targeting. Internalized nanoparticles traffic along endolysosomal compartments, endoplasmic reticulum and the Golgi complex. Nanoparticles have no detrimental effects on cell morphology and respiration.
Medical subject headings
- 3-Hydroxybutyric Acid
- Caproates
- Nanoparticles
- Polyethyleneimine