An enzymatic chromatin switch that directs formation of active brown fat.
Level V
Where this comes from
- Record sourced from PubMed, PMID 24411935.
- Also identified by DOI 10.1016/j.cmet.2013.12.011.
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Abstract
How is the recruitment of brown adipocytes regulated? Ohno et al. (2013) show that the euchromatic histone-lysine N-metyltransferase 1 (EHMT1) is essential for the specification of the brown adipocyte fate, a finding with important implications for the pathophysiology of obesity and obesity-related maladies.
Medical subject headings
- Adipose Tissue, Brown
- Cell Differentiation
- DNA-Binding Proteins
- Histone-Lysine N-Methyltransferase
- Thermogenesis
- Transcription Factors