NCOA5, IL-6, type 2 diabetes, and HCC: The deadly quartet.
Level V
Where this comes from
- Record sourced from PubMed, PMID 24411937.
- Also identified by DOI 10.1016/j.cmet.2013.12.010 and PMC identifier 3947913.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Although type 2 diabetes (T2D) is an established risk factor for hepatocellular carcinoma (HCC), the underlying mechanism that connects these two diseases is unknown. Gao et al. (2013) now suggest that nuclear receptor coactivator 5 (NCOA5) provides a genetic link between the two diseases through its effects on hepatic IL-6 expression.
Medical subject headings
- Carcinoma, Hepatocellular
- Glucose Intolerance
- Haploinsufficiency
- Liver Neoplasms
- Nuclear Receptor Coactivators