HIV-1 persistence in CD4+ T cells with stem cell-like properties.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24412925.
- Also identified by DOI 10.1038/nm.3445 and PMC identifier 3959167.
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Abstract
Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely defined. We show that during suppressive antiretroviral therapy, CD4(+) T memory stem cells (TSCM cells) harbor high per-cell levels of HIV-1 DNA and make increasing contributions to the total viral CD4(+) T cell reservoir over time. Moreover, we conducted phylogenetic studies that suggested long-term persistence of viral quasispecies in CD4(+) TSCM cells. Thus, HIV-1 may exploit the stem cell characteristics of cellular immune memory to promote long-term viral persistence.
Medical subject headings
- CD4-Positive T-Lymphocytes
- Disease Reservoirs
- HIV Infections
- HIV-1
- Lymphoid Progenitor Cells
- Phylogeny
- Virus Latency