EC-BLAST: a tool to automatically search and compare enzyme reactions.
basic_science · Level V
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- Record sourced from PubMed, PMID 24412978.
- Also identified by DOI 10.1038/nmeth.2803 and PMC identifier 4122987.
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Abstract
We present EC-BLAST (http://www.ebi.ac.uk/thornton-srv/software/rbl/), an algorithm and Web tool for quantitative similarity searches between enzyme reactions at three levels: bond change, reaction center and reaction structure similarity. It uses bond changes and reaction patterns for all known biochemical reactions derived from atom-atom mapping across each reaction. EC-BLAST has the potential to improve enzyme classification, identify previously uncharacterized or new biochemical transformations, improve the assignment of enzyme function to sequences, and assist in enzyme engineering.
Medical subject headings
- Algorithms
- Databases, Protein
- Enzymes
- Software