A bioinformatician's guide to the forefront of suffix array construction algorithms.

Shrestha, Anish Man Singh; Frith, Martin C; Horton, Paul · Brief Bioinform · 2014

basic_science · Level V

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Abstract

The suffix array and its variants are text-indexing data structures that have become indispensable in the field of bioinformatics. With the uninitiated in mind, we provide an accessible exposition of the SA-IS algorithm, which is the state of the art in suffix array construction. We also describe DisLex, a technique that allows standard suffix array construction algorithms to create modified suffix arrays designed to enable a simple form of inexact matching needed to support 'spaced seeds' and 'subset seeds' used in many biological applications.

Medical subject headings