Realizing the promise of cancer predisposition genes.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 24429628.
- Also identified by DOI 10.1038/nature12981 and PMC identifier 4975511.
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Abstract
Genes in which germline mutations confer highly or moderately increased risks of cancer are called cancer predisposition genes. More than 100 of these genes have been identified, providing important scientific insights in many areas, particularly the mechanisms of cancer causation. Moreover, clinical utilization of cancer predisposition genes has had a substantial impact on diagnosis, optimized management and prevention of cancer. The recent transformative advances in DNA sequencing hold the promise of many more cancer predisposition gene discoveries, and greater and broader clinical applications. However, there is also considerable potential for incorrect inferences and inappropriate clinical applications. Realizing the promise of cancer predisposition genes for science and medicine will thus require careful navigation.
Medical subject headings
- Carcinogenesis
- Genetic Predisposition to Disease
- Neoplasms