The multilayered complexity of ceRNA crosstalk and competition.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 24429633.
- Also identified by DOI 10.1038/nature12986 and PMC identifier 4113481.
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Abstract
Recent reports have described an intricate interplay among diverse RNA species, including protein-coding messenger RNAs and non-coding RNAs such as long non-coding RNAs, pseudogenes and circular RNAs. These RNA transcripts act as competing endogenous RNAs (ceRNAs) or natural microRNA sponges - they communicate with and co-regulate each other by competing for binding to shared microRNAs, a family of small non-coding RNAs that are important post-transcriptional regulators of gene expression. Understanding this novel RNA crosstalk will lead to significant insight into gene regulatory networks and have implications in human development and disease.
Medical subject headings
- Binding, Competitive
- MicroRNAs