Hyperthermia-induced drug delivery from thermosensitive liposomes encapsulated in an injectable hydrogel for local chemotherapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24436226.
- Also identified by DOI 10.1002/adhm.201300649.
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Abstract
A novel drug delivery system, enabling an in situ, thermally triggered drug release is described, consisting of an injectable thermoresponsive chitosan hydrogel containing doxorubicin-loaded thermosensitive liposomes. The design, fabrication, characterization, and an assessment of in vitro bioactivity of this formulation is detailed. Combining on-demand drug delivery with in situ gelation results in a promising candidate for local chemotherapy.
Medical subject headings
- Hydrogel, Polyethylene Glycol Dimethacrylate
- Liposomes