Proliferating macrophages populate established atherosclerotic lesions.
Where this comes from
- Record sourced from PubMed, PMID 24436425.
- Also identified by DOI 10.1161/CIRCRESAHA.113.302813 and PMC identifier 4332765.
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Abstract
A new study reveals that the majority of macrophages in established atherosclerotic lesions are derived from local proliferation, rather than from the influx of blood-borne monocytes. While the factors driving proliferation remain to be understood, the findings suggest that targeting macrophage proliferation could represent a new therapeutic opportunity in established atherosclerosis.
Medical subject headings
- Atherosclerosis
- Cell Proliferation
- Macrophages