Bistable parvalbumin circuits pivotal for brain plasticity.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24439367.
- Also identified by DOI 10.1016/j.cell.2013.12.034 and PMC identifier 4183967.
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Abstract
Experience shapes brain function throughout life to varying degrees. In a recent issue of Nature, Donato et al. identify reversible shifts in focal parvalbumin cell state during adult learning, placing it on a mechanistic continuum with developmental critical periods. A disinhibitory microcircuit controls the plasticity switch to modulate memory formation.
Medical subject headings
- Hippocampus
- Interneurons
- Learning
- Neuronal Plasticity
- Parvalbumins