Nrf1 to the rescue.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24448411.
- Also identified by DOI 10.7554/eLife.02062 and PMC identifier 3896943.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
When the level of proteasomal activity in a cell drops off, a transcription factor called Nrf1 travels to the nucleus to activate the genes that code for proteasomes.
Medical subject headings
- Adenosine Triphosphatases
- Cell Cycle Proteins
- Endoplasmic Reticulum
- Nuclear Respiratory Factor 1
- Proteasome Endopeptidase Complex
- Proteasome Inhibitors