Microfluidic assembly of multistage porous silicon-lipid vesicles for controlled drug release.

Herranz-Blanco, Bárbara; Arriaga, Laura R; Mäkilä, Ermei; Correia, Alexandra; Shrestha, Neha; Mirza, Sabiruddin; Weitz, David A; Salonen, Jarno et al. · Lab Chip · 2014

review · Level V

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Abstract

A reliable microfluidic platform for the generation of stable and monodisperse multistage drug delivery systems is reported. A glass-capillary flow-focusing droplet generation device was used to encapsulate thermally hydrocarbonized porous silicon (PSi) microparticles into the aqueous cores of double emulsion drops, yielding the formation of a multistage PSi-lipid vesicle. This composite system enables a large loading capacity for hydrophobic drugs.

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