Single cell transfection with single molecule resolution using a synthetic nanopore.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24471806.
- Also identified by DOI 10.1021/nl403789z.
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Abstract
We report the development of a single cell gene delivery system based on electroporation using a synthetic nanopore, that is not only highly specific and very efficient but also transfects with single molecule resolution at low voltage (1 V) with minimal perturbation to the cell. Such a system can be used to control gene expression with unprecedented precision--no other method offers such capabilities.
Medical subject headings
- Cell Membrane
- Electroporation
- Nanocapsules
- Nanopores
- Plasmids
- Silicon Compounds