Reprogramming the cardiac field.
Level V
Where this comes from
- Record sourced from PubMed, PMID 24481840.
- Also identified by DOI 10.1161/CIRCRESAHA.113.302946 and PMC identifier 4046860.
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Abstract
Two recent reports show that it is possible to reprogram somatic cells to a stem cell state using only a chemical cocktail or by inducing genes in tissues of engineered mice. These studies herald a time when cellular plasticity can be manipulated directly in the body to regenerate damaged tissues and organs. How do we go from these milestones to therapeutic heart regeneration?
Medical subject headings
- Cell Engineering
- Cellular Reprogramming
- Fibroblasts
- Induced Pluripotent Stem Cells
- Small Molecule Libraries
- Teratoma
- Totipotent Stem Cells