Voltage-dependent properties of DNA origami nanopores.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24484535.
- Also identified by DOI 10.1021/nl404183t.
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Abstract
We show DNA origami nanopores that respond to high voltages by a change in conformation on glass nanocapillaries. Our DNA origami nanopores are voltage sensitive as two distinct states are found as a function of the applied voltage. We suggest that the origin of these states is a mechanical distortion of the DNA origami. A simple model predicts the voltage dependence of the structural change. We show that our responsive DNA origami nanopores can be used to lower the frequency of DNA translocation by 1 order of magnitude.
Medical subject headings
- DNA
- Electrochemical Techniques
- Models, Chemical
- Nanopores