Golgi feels DNA's pain.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24485446.
- Also identified by DOI 10.1016/j.cell.2014.01.030.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The Golgi apparatus consists of disc-like cisternae, stretching around the nucleus through forces exerted by F-actin and the Golgi membrane protein GOLPH3. Farber-Katz et al. now report that DNA damage triggers Golgi dispersal and inhibits vesicular transport through DNA-PK-mediated GOLPH3 phosphorylation, thereby linking the DNA damage response to Golgi regulation.
Medical subject headings
- DNA Damage
- DNA-Activated Protein Kinase
- Golgi Apparatus
- Membrane Proteins
- Myosins