HIF meets NF-κB signaling.
Level V
Where this comes from
- Record sourced from PubMed, PMID 24487361.
- Also identified by DOI 10.1038/ki.2013.362.
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Abstract
An inflammatory stimulus prior to an ischemic insult can be protective in acute kidney injury (AKI) as well as other acute organ injury models, an effect called cross-tolerance. He et al. investigated mechanisms of cross-tolerance whereby pretreatment with lipopolysaccharide (LPS) protects from a subsequent ischemic insult of the kidney. The protection was mediated by LPS-induced nuclear factor-κB and hypoxia-inducible factor-2α (HIF-2α) signaling. These results link two central cellular pathways and give new insight into HIF-mediated renoprotection in AKI models.
Medical subject headings
- Acute Kidney Injury
- Basic Helix-Loop-Helix Proteins
- Kidney
- Lipopolysaccharides
- Nitric Oxide
- Reperfusion Injury