Lipoprotein glomerulopathy may provide a key to unlock the puzzles of renal lipidosis.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 24487366.
- Also identified by DOI 10.1038/ki.2013.404.
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Abstract
Lipoprotein glomerulopathy is an inherited renal disease characterized by unique lipoprotein thrombi in the glomerulus and is associated with the APOE mutation. Hu and colleagues investigated the genetic and clinical features of a large group of patients with lipoprotein glomerulopathy who carried APOE Kyoto, a major APOE variant. Their findings suggest its descent through a founder effect. Fibrate therapy in this group showed favorable results in the patient and renal survival rates.
Medical subject headings
- Apolipoprotein E2
- Fenofibrate
- Hypolipidemic Agents
- Kidney
- Kidney Diseases
- Mutation