Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 24487640.
- Also identified by DOI 10.1172/JCI70050 and PMC identifier 3904610.
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Abstract
During bone resorption, abundant factors previously buried in the bone matrix are released into the bone marrow microenvironment, which results in recruitment and differentiation of bone marrow mesenchymal stem cells (MSCs) for subsequent bone formation, temporally and spatially coupling bone remodeling. Parathyroid hormone (PTH) orchestrates the signaling of many pathways that direct MSC fate. The spatiotemporal release and activation of matrix TGF-β during osteoclast bone resorption recruits MSCs to bone-resorptive sites. Dysregulation of TGF-β alters MSC fate, uncoupling bone remodeling and causing skeletal disorders. Modulation of TGF-β or PTH signaling may reestablish coupled bone remodeling and be a potential therapy.
Medical subject headings
- Bone Marrow Cells
- Bone Remodeling
- Gene Expression Regulation
- Mesenchymal Stem Cells
- Parathyroid Hormone
- Transforming Growth Factor beta