Facing the truth about nanotechnology in drug delivery.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24490875.
- Also identified by DOI 10.1021/nn404501g and PMC identifier 3914010.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Nanotechnology in drug delivery has been manifested into nanoparticles that can have unique properties both in vitro and in vivo, especially in targeted drug delivery to tumors. Numerous nanoparticle formulations have been designed and tested to great effect in small animal models, but the translation of the small animal results to clinical success has been limited. Successful translation requires revisiting the meaning of nanotechnology in drug delivery, understanding the limitations of nanoparticles, identifying the misconceptions pervasive in the field, and facing inconvenient truths. Nanoparticle approaches can have real impact in improving drug delivery by focusing on the problems at hand, such as enhancing their drug loading capacity, affinity to target cells, and spatiotemporal control of drug release.
Medical subject headings
- Disclosure
- Drug Delivery Systems
- Nanocapsules
- Nanotechnology
- Translational Research, Biomedical