JMJD6 regulates ERα methylation on arginine.
basic_science · Level V
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- Record sourced from PubMed, PMID 24498420.
- Also identified by DOI 10.1371/journal.pone.0087982 and PMC identifier 3912157.
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Abstract
ERα functions are tightly controlled by numerous post-translational modifications including arginine methylation, which is required to mediate the extranuclear functions of the receptor. We report that upon oestrogenic stimulation, JMJD6, the only arginine demethylase described so far, interacts with and regulates methylated ERα (metERα) function. Moreover, by combining the silencing of JMJD6 with demethylation assays, we show that metERα is a new substrate for JMJD6. We propose that the demethylase activity of JMJD6 is a decisive regulator of the rapid physiological responses to oestrogen.
Medical subject headings
- Arginine
- Breast Neoplasms
- DNA Methylation
- Estrogen Receptor alpha
- Gene Expression Regulation, Neoplastic
- Jumonji Domain-Containing Histone Demethylases
- Protein Processing, Post-Translational