Low concentrations of HIV-1 DNA at birth delays diagnosis, complicating identification of infants for antiretroviral therapy to potentially prevent the establishment of viral reservoirs.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 24501389.
- Also identified by DOI 10.1093/cid/ciu068 and PMC identifier 3967830.
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Abstract
Among infants exposed to human immunodeficiency virus type 1 (HIV-1), detection of viral infection at birth was increased by 39% (95% confidence interval, 19%-47%) by increasing DNA input from dried blood spots into polymerase chain reaction. Infants with low concentrations of HIV-1 at birth may be the best target population to evaluate whether immediate antiretroviral therapy can prevent long-term infection.
Medical subject headings
- Anti-Retroviral Agents
- DNA, Viral
- HIV Infections
- HIV-1
- Viral Load