High-density lipoproteins put out the fire.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24506861.
- Also identified by DOI 10.1016/j.cmet.2014.01.009 and PMC identifier 3962668.
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Abstract
Macrophages in atherosclerotic plaques are activated, inflammatory cells that directly contribute to the disease process. De Nardo et al. (2013), now report that high-density lipoproteins (HDL) can reprogram macrophages to be less inflammatory through an ATF3-dependent pathway, providing another mechanistic basis for the atheroprotective properties of HDL.
Medical subject headings
- Activating Transcription Factor 3
- Anti-Inflammatory Agents, Non-Steroidal
- Atherosclerosis
- Cholesterol
- Inflammation
- Lipoproteins, HDL
- Macrophages