NAD+ deficiency in age-related mitochondrial dysfunction.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24506863.
- Also identified by DOI 10.1016/j.cmet.2014.01.005.
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Abstract
Age-related mitochondrial dysfunction is thought to contribute to mammalian aging, particularly in postmitotic tissues that rely heavily on oxidative phosphorylation. A new study (Gomes et al., 2013) shows that reduced levels of nicotinamide adenine dinucleotide (NAD(+)) contribute to the mitochondrial decay associated with skeletal muscle aging and that sirtuin 1 (SIRT1) modulates this process.
Medical subject headings
- Aging
- Cell Nucleus
- Mitochondria
- NAD
- Oxidative Phosphorylation