Getting off the ground state: X chromosome inactivation knocks down barriers to differentiation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24506876.
- Also identified by DOI 10.1016/j.stem.2014.01.012 and PMC identifier 3984128.
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Abstract
Female mouse embryonic stem cells (mESCs) contain two active X chromosomes, with one undergoing random inactivation upon differentiation. Schulz et al. (2014) now demonstrate that the presence of two active X chromosomes in mESCs prevents exit from pluripotency by blocking MAPK signaling, ensuring synchronization between X chromosome dosage compensation and development.
Medical subject headings
- Killer Cells, Natural