Turning reactive glia into functional neurons in the brain.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24506877.
- Also identified by DOI 10.1016/j.stem.2014.01.010 and PMC identifier 4018986.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Following brain injury, reactive glial cells can create scars that inhibit neural repair responses. In this issue of Cell Stem Cell, Guo et al. report that overexpression of NeuroD1 in vivo can directly reprogram reactive glial cells into glutamatergic and GABAergic neurons that integrate into the host's neural circuitry.
Medical subject headings
- Alzheimer Disease
- Brain Injuries
- Cellular Reprogramming
- Neuroglia
- Neurons