Radiation redux: reserve intestinal stem cells miss the call to duty.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24506878.
- Also identified by DOI 10.1016/j.stem.2014.01.015 and PMC identifier 3955177.
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Abstract
Distinct stem cell populations in intestinal crypts mediate tissue homeostasis and responses to epithelial damage such as radiation. Now in Cell Stem Cell, Metcalfe et al. (2014) demonstrate that homeostatic, proliferative Lrg5(+) cells are necessary to regenerate the epithelium after radiation, whereas quiescent Lgr5(-) reserve stem cells are surprisingly radiosensitive.
Medical subject headings
- Intestines
- Radiation, Ionizing
- Receptors, G-Protein-Coupled
- Regeneration
- Stem Cells