mTORC1: turning off is just as important as turning on.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24529368.
- Also identified by DOI 10.1016/j.cell.2014.01.057.
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Abstract
mTORC1 is activated primarily on the lysosome. Menon et al. and Demetriades et al. show that mTORC1 deactivation on the lysosome is determined by recruitment of its negative regulator, the tumor suppressor complex TSC1-TSC2. These reports highlight the importance of subcellular localization in the regulation of mTORC1.
Medical subject headings
- Amino Acids
- Insulin
- Lysosomes
- Multiprotein Complexes
- Signal Transduction
- TOR Serine-Threonine Kinases
- Tumor Suppressor Proteins