miniMAVS, You Complete Me!
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24529369.
- Also identified by DOI 10.1016/j.cell.2014.01.045 and PMC identifier 5097455.
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Abstract
The functional significance of protein diversification through translational regulation in mammals is largely unexplored. Brubaker et al. now describe the generation of two functionally distinct mammalian proteins, MAVS and miniMAVS, from a single bicistronic mRNA and suggest that noncanonical translation may impact multiple players in innate immune regulation.
Medical subject headings
- Adaptor Proteins, Signal Transducing
- Gene Expression Regulation
- Immunity, Innate
- Protein Biosynthesis