Structural insights on the role of antibodies in HIV-1 vaccine and therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24529371.
- Also identified by DOI 10.1016/j.cell.2014.01.052 and PMC identifier 4041625.
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Abstract
Despite 30 years of effort, there is no effective vaccine for HIV-1. However, antibodies can prevent HIV-1 infection in humanized mice and macaques when passively transferred. New single-cell-based methods have uncovered many broad and potent donor-derived antibodies, and structural studies have revealed the molecular bases for their activities. The new data suggest why such antibodies are difficult to elicit and inform HIV-1 vaccine development efforts. In addition to protecting against infection, the newly identified antibodies can suppress active infections in mice and macaques, suggesting they could be valuable additions to anti-HIV-1 therapies and to strategies to eradicate HIV-1 infection.
Medical subject headings
- AIDS Vaccines
- HIV Antibodies
- HIV Infections
- HIV-1