Targeted in vivo imaging of microscopic tumors with ferritin-based nanoprobes across biological barriers.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24532221.
- Also identified by DOI 10.1002/adma.201304544.
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Abstract
The avascular microscopic breast and brain tumors (<1-2 mm diameter) can be noninvasively detected by designing human heavy-chain ferritin (HFn)-based nanoparticles as molecular probes for near-infrared fluorescence and magnetic resonance imaging. The intravenously injected HFn-based nano-particles (Cy5.5-HFn and M-HFn) can cross the endothelium, epithelium, and blood-brain barriers and be internalized into tumor cells.
Medical subject headings
- Contrast Media
- Ferritins
- Magnetic Resonance Imaging
- Nanoparticles