Prodrug strategy to achieve lyophilizable, high drug loading micelle formulations through diester derivatives of β-Lapachone.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24532286.
- Also identified by DOI 10.1002/adhm.201300590 and PMC identifier 4133338.
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Abstract
β-Lap prodrug micelle strategy improves the formulation properties of β-lap therapeutics. The resulting micelles yield apparent high β-lap solubility (>7 mg mL(-1) ), physical stability, and ability to reconstitute after lyophilization. In the presence of esterase, β-lap prodrugs are efficiently converted into parent drug (i.e., β-lap), resulting in NQO1-dependent lethality of NSCLC cells.
Medical subject headings
- Micelles
- Naphthoquinones
- Prodrugs