Nucleotides as nontoxic endogenous endosomolytic agents in drug delivery.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24535942.
- Also identified by DOI 10.1002/adhm.201400008.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Nontoxic endogenous nucleotides such as adenosine triphosphate and guanosine triphosphate have secondary phosphate groups, causing proton-buffering capacity and/or hemolytic activity in endolysosomal pH ranges. Nucleotides co-delivered in single polymeric pDNA nanocarrier induce highly enhanced transfection efficiency with negligible cytotoxicity due to their endosomolytic functions.
Medical subject headings
- Drug Delivery Systems
- Nanostructures
- Nucleotides