Molecular precision chemotherapy: overcoming resistance to targeted therapies?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 24536061.
- Also identified by DOI 10.1158/1078-0432.CCR-13-3194.
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Abstract
Cytotoxic drugs may have specific effects on oncogenes and their downstream targets. Increase of cancer cell sensitivity due to repression of an oncogene downstream target can be specifically addressed by combined precision chemotherapy, increasing the therapeutic index of chemotherapy and overcoming resistance to highly selective targeted therapies.
Medical subject headings
- Antineoplastic Agents
- Camptothecin
- DNA Damage
- Dioxoles
- Oncogene Proteins, Fusion
- Proto-Oncogene Protein c-fli-1
- RNA-Binding Protein EWS
- Sarcoma, Ewing
- Tetrahydroisoquinolines