3D bioprinting of vascularized, heterogeneous cell-laden tissue constructs.

Kolesky, David B; Truby, Ryan L; Gladman, A Sydney; Busbee, Travis A; Homan, Kimberly A; Lewis, Jennifer A · Adv Mater · 2014

basic_science · Level V

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Abstract

A new bioprinting method is reported for fabricating 3D tissue constructs replete with vasculature, multiple types of cells, and extracellular matrix. These intricate, heterogeneous structures are created by precisely co-printing multiple materials, known as bioinks, in three dimensions. These 3D micro-engineered environments open new -avenues for drug screening and fundamental studies of wound healing, angiogenesis, and stem-cell niches.

Medical subject headings