Evidence for influenza virus CNS invasion along the olfactory route in an immunocompromised infant.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 24550441.
- Also identified by DOI 10.1093/infdis/jiu097.
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Abstract
Central nervous system (CNS) disease is the most common extrarespiratory complication of influenza in humans. However, the pathogenesis, including the route of virus entry, is largely unknown. Here we present, for the first time, evidence of influenza virus entry into the CNS via the olfactory route in an immune-compromised infant. Since the nasal cavity is a primary site of influenza virus replication and is directly connected to the CNS via the olfactory nerve, these results imply that influenza virus invasion of the CNS may occur more often than previously believed.
Medical subject headings
- Central Nervous System Infections
- Influenza A virus
- Influenza, Human
- Olfactory Bulb
- Orthomyxoviridae