Particle replication in nonwetting templates nanoparticles with tumor selective alkyl silyl ether docetaxel prodrug reduces toxicity.
Where this comes from
- Record sourced from PubMed, PMID 24552251.
- Also identified by DOI 10.1021/nl4046558 and PMC identifier 4157645.
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Abstract
Delivery systems designed to have triggered release after passively targeting the tumor may improve small molecule chemotherapeutic delivery. Particle replication in nonwetting templates was used to prepare nanoparticles to passively target solid tumors in an A549 subcutaneous xenograft model. An acid labile prodrug was delivered to minimize systemic free docetaxel concentrations and improve tolerability without compromising efficacy.
Medical subject headings
- Drug Carriers
- Nanoparticles
- Neoplasms
- Prodrugs
- Taxoids