Hippocampal synaptic plasticity, spatial memory and anxiety.
review · Level V
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- Record sourced from PubMed, PMID 24552786.
- Also identified by DOI 10.1038/nrn3677.
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Abstract
Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories. However, it may not be the synaptic plasticity-dependent memory hypothesis that is wrong; instead, it may be the role of the hippocampus that needs to be re-examined. We present an account of hippocampal function that explains its role in both memory and anxiety.
Medical subject headings
- Anxiety
- Hippocampus
- Memory
- Neuronal Plasticity
- Space Perception
- Synapses