Cell biology: Stressful genetics in Crohn's disease.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24553137.
- Also identified by DOI 10.1038/nature13060 and PMC identifier 4420161.
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Abstract
A common variant of the autophagy protein ATG16L1 is a risk factor for Crohn’s disease. But the genetic alteration is revealed only when the protein is cleaved by the enzyme caspase 3 during cellular stress.
Medical subject headings
- Carrier Proteins
- Caspase 3
- Crohn Disease
- Polymorphism, Single Nucleotide
- Proteolysis