Modification of biomaterials with a self-protein inhibits the macrophage response.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24573988.
- Also identified by DOI 10.1002/adhm.201300532 and PMC identifier 4272238.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
A biomaterial inhibits the host immune response by displaying an endo-genously expressed immunomodulatory molecule, CD200. Immobilization of CD200 onto biomaterial surfaces effectively suppresses macrophage activation and reduces inflammatory response to subcutaneously implanted materials.
Medical subject headings
- Antigens, CD
- Biocompatible Materials
- Immobilized Proteins
- Macrophages