Peptide-directed spatial organization of biomolecules in dynamic gradient scaffolds.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24574189.
- Also identified by DOI 10.1002/adhm.201400032.
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Abstract
Specific binding peptides are used to spatially organize biomolecule gradients within an electrospun fiber scaffold. Different biomolecule-binding peptide-polymer conjugates are sequentially co-electrospun with a fiber-forming host polymer to generate opposing gradients of peptide functionalization. The binding peptides specifically and non-covalently guide the spatial arrangement of biomolecules into dynamic gradients within the scaffold, mimicking biological gradients found in native tissues.
Medical subject headings
- Hyaluronic Acid
- Peptides
- Polyesters
- Tissue Scaffolds