Enhanced intracellular siRNA delivery using bioreducible lipid-like nanoparticles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24574196.
- Also identified by DOI 10.1002/adhm.201400039.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
A new library of lipid-like nanoparticles (lipidoids) comprising disulfide bond is developed for siRNA delivery. Bioreducible lipidoids deliver siRNA with greater efficiency than nonbioreducible lipidoids with similar chemical structures. A siRNA release investigation, as well as an intracellular siRNA trafficking study, reveals that the degradation of bioreducible lipidoid in a strongly reductive intracellular environment boosts siRNA release and enhances siRNA gene knockdown efficiency.
Medical subject headings
- Gene Knockdown Techniques
- Intracellular Space
- Lipids
- Nanoparticles
- RNA, Small Interfering