Ribosome rescue, nearing the end.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24581485.
- Also identified by DOI 10.1016/j.cell.2014.02.028.
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Abstract
In eukaryotes, Dom34 is involved in the rescue of ribosomes that stall on mRNAs during protein synthesis. Using ribosome profiling, Guydosh and Green reveal that, in addition to rescue of ribosomes stalled on truncated mRNAs, Dom34 also recycles ribosomes that are unexpectedly found in the 3' untranslated regions of many cellular mRNAs.
Medical subject headings
- 3' Untranslated Regions
- Cell Cycle Proteins
- Endoribonucleases
- Ribosomes
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins