Nuclear pores set the speed limit for mitosis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24581486.
- Also identified by DOI 10.1016/j.cell.2014.02.004 and PMC identifier 4008093.
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Abstract
The spindle assembly checkpoint prevents separation of sister chromatids until each kinetochore is attached to the mitotic spindle. Rodriguez-Bravo et al. report that the nuclear pore complex scaffolds spindle assembly checkpoint signaling in interphase, providing a store of inhibitory signals that limits the speed of the subsequent mitosis.
Medical subject headings
- Anaphase
- Cell Cycle Proteins
- M Phase Cell Cycle Checkpoints
- Mad2 Proteins
- Nuclear Pore
- Nuclear Proteins