Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5.
basic_science · Level V
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- Record sourced from PubMed, PMID 24594601.
- Also identified by DOI 10.1073/pnas.1400350111 and PMC identifier 3964128.
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Abstract
The mechanism by which the 8q24 MYC enhancer region, including cancer-associated variant rs6983267, increases cancer risk is unknown due to the lack of protein-coding genes at 8q24.21. Here we report the identification of long noncoding RNAs named cancer-associated region long noncoding RNAs (CARLos) in the 8q24 region. The expression of one of the long noncoding RNAs, CARLo-5, is significantly correlated with the rs6983267 allele associated with increased cancer susceptibility. We also found the MYC enhancer region physically interacts with the active regulatory region of the CARLo-5 promoter, suggesting long-range interaction of MYC enhancer with the CARLo-5 promoter regulates CARLo-5 expression. Finally, we demonstrate that CARLo-5 has a function in cell-cycle regulation and tumor development. Overall, our data provide a key of the mystery of the 8q24 gene desert.
Medical subject headings
- Chromosomes, Human, Pair 8
- Gene Expression Regulation, Neoplastic
- Genetic Predisposition to Disease
- Neoplasms
- RNA, Long Noncoding