Estrogen regulates the tumour suppressor MiRNA-30c and its target gene, MTA-1, in endometrial cancer.
basic_science · Level V
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- Record sourced from PubMed, PMID 24595016.
- Also identified by DOI 10.1371/journal.pone.0090810 and PMC identifier 3940948.
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Abstract
MicroRNA-30c (miR-30c) has been reported to be a tumour suppressor in endometrial cancer (EC). We demonstrate that miR-30c is down-regulated in EC tissue and is highly expressed in estrogen receptor (ER)-negative HEC-1-B cells. MiR-30c directly inhibits MTA-1 expression and functions as a tumour suppressor via the miR-30c-MTA-1 signalling pathway. Furthermore, miR-30c is decreased upon E2 treatment in both ER-positive Ishikawa and ER-negative HEC-1-B cells. Taken together, our results suggest that miR-30c is an important deregulated miRNA in EC and might serve as a potential biomarker and novel therapeutic target for EC.
Medical subject headings
- Endometrial Neoplasms
- Estrogens
- Gene Expression Regulation, Neoplastic
- Histone Deacetylases
- MicroRNAs
- Repressor Proteins
- Signal Transduction